Paracellular claudin ion channels
Tight junction patch clamp recordings reveal dynamic gated claudin-2 cation channels.
Molecular dynamic model of claudin-15
All-atom model provides functional insight into the claudin-15 pore.
ZO-1 regulates AV node function
Cardiomyocyte specific knockout of ZO-1 results in AV block, but no change in ventricular conduction.
Tight junction changes are present in idiopathic pulmonary fibrosis
Findings suggest epithelial barrier alterations may be present in idiopathic pulmonary fibrosis, even in the absence of overt defects in the epithelial layer.
Patient-specific tumor models
Organoids share histologic and genetic features of pancreatic ductal adenocarcinomas.
Innovations in chemotherapy testing
Automated microfluidics platform allows high-throughput and precision testing of personalized cancer therapies using organoid models.
About Research Group
As a group we have diverse interests in understanding cellular mechanisms of disease. We have modeled action potentials in neurons, potassium channels in pancreatic beta cells, excitation contraction coupling in cardiomyocytes, and epithelial barrier function in the gut. The common theme is to define mechanisms of ion transport, to understand how transport is altered in disease, and to search for novel therapeutic approaches.
