Paracellular claudin ion channels

Tight junction patch clamp recordings reveal dynamic gated claudin-2 cation channels.

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Molecular dynamic model of claudin-15

All-atom model provides functional insight into the claudin-15 pore.

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TBX5-loss associated atrial fibrillation.

Calcium-dependent triggered activity and conduction velocity are driven by TBX5-loss.

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Patient-specific tumor models.

Organoids share histologic and genetic features of pancreatic ductal adenocarcinomas.

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About Research Group

As a group we have diverse interests in understanding cellular mechanisms of disease. We have modeled action potentials in neurons, potassium channels in pancreatic beta cells, excitation contraction coupling in cardiomyocytes, and epithelial barrier function in the gut. The common theme is to define mechanisms of ion transport, to understand how transport is altered in disease, and to search for novel therapeutic approaches.

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